Cerivastatin quells molecular mechanisms that cause breast cancer aggression.

2003 APR 8 - (NewsRx.com & NewsRx.net) -- Cerivastatin quells molecular mechanisms that cause breast cancer aggression.

"Statins are currently used for the treatment of hypercholesterolemia. Recently, we demonstrated that cerivastatin also reduces the proliferation and invasion of aggressive breast cancer cells, MDA-MB-231. In this report, a molecular mechanism to explain its anti-cancer action is proposed by combining the study of cerivastatin effect on both gene expression (microarray) and signal transduction pathways," researchers in France report.

"Firstly, the expression of 13 genes was modified by cerivastatin and confirmed at protein level. They …